Cellytics NK: A novel platform for efficient and precise NK cell activity evaluation — ASN Events
  1. Schedule
  2. Poster Session One
  3. Cellytics NK: A novel platform for efficient and precise NK cell activity evaluation

Cellytics NK: A novel platform for efficient and precise NK cell activity evaluation (#137)

Sunmi Han 1 2 , Inha Lee 1 , Yuyeon Jang 1 , Hyun S Jun 1 3 , Sungkyu Seo 1 2
  1. R&D Team, MetaImmuneTech Inc, Sejong, Republic of Korea
  2. Center for Advanced Photonic Materials, Korea University, Sejong, Sejong-si, South Korea
  3. Department of Biotechnology and Bioinformatics, Korea University, Sejong, Sejong, Republic of Korea

Cellytics NK is an innovative analytical platform that quantifies NK cell activity by algorithmically analyzing morphological changes in activated NK cells. Unlike conventional assays that rely on cytokine secretion or cytotoxicity measurements, Cellytics NK provides a label-free, rapid assessment of NK cell dynamics, offering a more precise and scalable approach for immune monitoring.

In this presentation, we will showcase three key clinical applications of Cellytics NK:

First, Immune Monitoring in Sterile Room Patients: Patients in sterile rooms are highly susceptible to infections due to severe immune suppression. In a study of leukemia patients in sterile rooms (N=14), Cellytics NK analysis showed significantly lower I3 values than healthy donors, reflecting compromised immune function.

Second, Alcoholic Liver Disease (ALD) Assessment: Alcoholic liver disease (ALD) is linked to impaired immune function and increased infection risk. Cellytics NK, by tracking NK cell activity, provides a biomarker for assessing disease progression and treatment response. In a study of ALD patients (fatty liver: N=17, cirrhosis: N=10), I3 values were elevated, with the highest levels in cirrhosis cases, suggesting hyperactivation of innate immunity.

Third, NK Cell Therapeutics Effect Monitoring: With the expansion of regenerative medicine, including immunotherapy and NK cell therapies, demand for NK cell activity monitoring has grown. Utilizing Cellytics NK’s accessibility and efficiency, a study monitored SCLC patients (N=8) on maintenance therapy with immune checkpoint inhibitors and autologous NK cell therapy. The results showed a trend of increased I3 values post-treatment, highlighting its potential for monitoring NK cell-based therapy effectiveness.

In conclusion, Cellytics NK demonstrates its potential as a valuable tool for patient monitoring across various immune-related conditions. Its ability to rapidly assess NK cell activity suggests that it can be effectively utilized for tracking patient status in cancer immunotherapy, infectious diseases, and other immune disorders.