Poster Session Two — ASN Events

Poster Session Two — ASN Events

Poster Session Two

Poster Session Two: Posters #191-#279 including oral abstracts

Chemically Primed Natural Killer Cells Overcome Acidic Stress by Maintaining Mitochondrial Integrity (#191)

Engineering allorejection-resistant adaptive NK cell therapies (#192)

The L48-H/R Polymorphism on CD16 Promotes Serial ADCC and Reduces NK Cell Exhaustion (#193)

Nicholas A Maskalenko

Dual antigen targeting using novel modular TriKE-PACCs enhances NK cell-mediated killing of AML cells (#194)

Anders W Matson

Glucocorticoids rewire NK cell metabolism (#195)

Myelofibrosis Patients with CALR, MPL, or Other Clonal Mutations Exhibit Dysfunctional NK Cells with Increased KIR2DL1 Inhibition (#196)

Mariana Medeiros

Hypermature but dysfunctional NK Cells is associated with Advanced Myelofibrosis (#197)

Mariana Medeiros

Genetic Modification of CAR NK Cells for Improved Therapeutic Efficacy Against Cancer (#198)

Response to g-NK therapy is associated with higher CD8+ T cells and lower MDSC in Bone Marrow of Multiple Myeloma Patients (#199)

NK cells from Patients with Follicular lymphoma Demonstrate Potent Anti-tumor Responses and Potential as Autologous Cellular Therapies (#200)

Sequencing of the Complete KIR3DL1 Gene Reveals a Soluble Protein Isoform (#201)

Lack of prenylation of small GTPases causes defective trafficking of cytolytic granules in NK cells in mice and humans with mevalonate kinase deficiency (#202)

Structural and functional analysis of the NK cell ADCC activation complex across biological scales (#203)

PIG Genes and ULBP2 Drive a Novel Mechanism of NK-Cell Mediated Cytotoxicity (#204)

Simon Nicoletti

Feeder Free Expanded Primary and iPSC-derived NK cells Maintain Cytotoxic Function Against Patient Derived 3D Tumoroids (#205)

Jasmine Padilla

Overcoming scalability challenges in allogeneic NK cell therapy using closed, automated systems (#206)

Jasmine Padilla

Chemical Priming Strategy to Enhance ADCC Efficacy of Natural Killer Cells against Multiple Myeloma (#207)

Development of GPC3 Targeting CAR-NK Cell with IL-15 Secretion for Treatment of Hepatocellular Carcinoma (#208)

Identification and Characterization of Human Antibodies Targeting the Human NKG2D Receptor (#209)

Matthew S Parsons

Deciphering the origin and development of tissue-resident ILCs from fetal to adult life (#210)

Identification and Characterisation of Natural Killer Cells in Zebrafish (#211)

Kaushalya Perera

Molecular basis of activating KIR2DS reactivity towards peptide-HLA-C ligands (#212)

Ksp37: a novel effector molecule poised for rapid release in functionally primed NK cells (#213)

Aline Pfefferle

Self-Amplifying RNA Outperforms Circular mRNA in Sustained CAR Expression and Cytotoxicity on NK-92 Cells (#214)

Virgínia Mrs. Picanço-Castro

Controlling HCMV Through NK-dependent ADCC-inducing Immunotherapies. (#215)

KIR2DS4 preferentially enhances the adaptive memory-like NK subset through NKG7 and IL15 in cytomegalovirus seropositive glioblastoma patients with improved survival outcome (#216)

Mohummad Aminur Rahman

Memory Natural Killer Cells: The Hidden Forces Combating Chronic Hepatitis B (#217)

Single cell profiling of human bone marrow reveals multiple myeloma progression is accompanied by an increase in CD56^bright bone marrow resident NK cells. (#218)

Elucidating the link between metabolic profile and NK cell function in the progression of multiple myeloma. (#219)

A Machine Learning Classifier to Automatically Label Conventional and Adoptively Transferred Memory-Like NK Cell Subsets within scRNA-seq Datasets (#220)

Harnessing CAR-NK Cell Therapy for Targeted Glioblastoma Treatment (#221)

Jérémy Robert

Different NK Cell Responses to Porcine Endothelial Cells and Red Blood Cells (#222)

The NK Cell Curriculum: the education pathway to achieve polyfunctionality (#223)

Luis Romero Martin

The ELK3-CYFIP2 Axis: A Key Regulator of Actin Dynamics and Natural Killer Cell Sensitivity in Triple-Negative Breast Cancer. (#224)

PRE-CLINICAL DEVELOPMENT OF BB-NK-001: AN ACADEMIC MEMORY-LIKE NK CELL THERAPY FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (#225)

Extended TGF-β exposure drives persistent NK cell dysfunction (#226)

Characterising NKp44-isoforms in NK cell surveillance of growth factors (#227)

Alexander Sedgwick

Af-CAR drives a unique phenotype in NK cells boosting their antifungal activity against Aspergillus fumigatus (#228)

Epigenetic determinants of Memory-Like NK cell differentiation (#229)

Unleashing the Cytotoxic Potential of NK-92 by CRISPR Genome Editing (#230)

NK cells from newly diagnosed Chronic Myeloid Leukemia Patients are benign: phenotypic and function characterization. (#231)

Characterization of Canine NK Cells Expanded Using K562 Cells Expressing Membrane-Bound IL-21 and 4-1BBL (#232)

Samantha Sommer

Uncovering Mechanisms of Enhanced NK Cytotoxicity in the Ovarian Cancer Microenvironment: Molecular Interactions and Therapeutic Potential (#233)

Terran D Stenger

Harnessing the Power of iPSC-NK Cells for Cancer Immunotherapy (#234)

ATF3 Restrains ILC1 Potency in Ameliorating CD8⁺T Cell-Mediated Viral Hepatitis (#235)

Cancer immunotherapy using ex vivo expanded natural killer cells in combination with monoclonal antibody drugs for advanced cancer (#236)

Hiroshi Terunuma

Phase II Trial of Haploidentical Hematopoietic Cell Transplantation (HCT), Natural Killer (NK) Cell Infusion, and Sirolimus Leads to Long-Term Survival in Select Patients with High-Risk Solid Tumors (#237)

Monica S. Thakar

Central Production and Multi-Site Distribution of Expanded Donor Derived Natural Killer (NK) Cell Immunotherapy in Time Sensitive Clinical Situations (#238)

Monica S. Thakar

Intratumor Microbiome and Tumor-Associated Macrophage Interaction in the Tumor Microenvironment Impacts Metastasis Risk in Early-Stage Colorectal Carcinomas (#239)

Rapid and Efficient Engineering of Primary NK Cells with NKG2A Knockout and A/C Switch to Overcome HLA-E-mediated Immune Suppression (#240)

Lamberto Torralba-Raga

Role of CD8+ NK cells in the natural control of SIV infection in baboons (#241)

Benjamin Turbow

TRANSCRIPTIONAL AND FUNCTIONAL CHARACTERISATION OF DNAM-1+2B4 SYNERGYSM (#242)

Tania Allin Vargas Pavia

Impact of Calcium Signaling on Immune Evasion of Leukemic Blasts from NK Cells (#243)

Vitamin A and D modulate tissue residency in human natural killer cells (#244)

HIF2α deficiency improves NK cell antitumor activities in the hypoxia tumor microenvironment (#245)

Transcriptomic and phosphoproteomic characterization of CAR-NK signaling (#246)

The Impact of Tissue-Resident NK Cells on the Pathogenesis of Juvenile Idiopathic Arthritis (#247)

Kentaro Yomogida

CD200R blockade enhances anti-tumor immunity by unleashing NK and CD8⁺ T cells in tumor (#248)

zhengfeng Zhang

P2RX7 signaling restrains ILC1-mediated antitumor immunity (#249)

Engineering Natural Killer Cells to Secrete Engager Molecules Targeting B7-H3 (#250)

Nicholas A Zorko

PD-L1 ligation on NK cells induces metabolic shift from glycolysis to fatty acid oxidation, enhancing tumor infiltration and control (#253)

Buddy-CAR-NK cells: IL7/IL7R-engineered CAR-NK cells show enhanced proliferation and anti-tumor function while modulating the TME through paracrine T cell activation (#255)

Engineering of a novel nanomaterial-based biodegradable scaffold for efficient memory-like differentiation, expansion and transduction of NK cells (#256)

Single-cell analyses reveal key NK cell subsets associated with response to PD-L1 blockade in hepatocellular carcinoma (#278)